Celebrity GLP-1 and Ozempic Weight Loss Transformations
Semaglutide and tirzepatide changed Hollywood faster than any diet trend in decades. Ozempic, Wegovy, Mounjaro and Zepbound were approved for type 2 diabetes and obesity — but by 2022 they’d become the worst-kept secret on every red carpet, and the whisper campaign turned into a full-blown cultural argument.
Some stars got ahead of it and told the truth. Others denied it, sued over it, or quietly changed the subject. Below are the celebrities who have actually confirmed GLP-1 use in their own words, with real quotes, real dates and the body stats to go with them. No speculation — just what they said on the record.
1. Oprah Winfrey
Oprah went public in a December 2023 People cover story, confirming she uses a prescription weight-loss medication as a “maintenance tool.” The 5 ft 7 in media mogul has battled her weight on camera since 1988, hitting a peak of 237 lbs in 1992.
She followed it with an ABC primetime special, Shame, Blame and the Weight Loss Revolution, on March 18, 2024, and stepped down from the WeightWatchers board that February, donating her shares. She pairs the medication with daily hiking and a 7:30 p.m. eating cutoff.
2. Elon Musk
Musk was one of the first A-listers to say it out loud. In October 2022, asked on Twitter how he looked “fit, ripped and healthy,” he replied: “Fasting” — then added “Wegovy.” He’s said he dropped around 30 lbs.
The 6 ft 2 in Tesla CEO later posted that he’d moved to tirzepatide and joked about being “Ozempic Santa” in a November 2024 post. He combines the injections with periodic fasting and skipping breakfast.
3. Sharon Osbourne
Sharon’s is the cautionary tale. The 5 ft 2 in TV personality confirmed in 2023 that she used Ozempic for four months and lost 42 lbs, dropping to around 91 lbs at her lowest.
On Bill Maher’s Club Random she said she went “too far” and couldn’t put the weight back on afterward, warning younger women against using the drug cosmetically. She’s since said she’s tried to gain weight and can’t.
4. Amy Schumer
Schumer told Watch What Happens Live in 2023 that she tried Ozempic and quit almost immediately: “I was like, ‘I can’t live like this.'” She said she was vomiting, bedridden and unable to play with her son.
The 5 ft 7 in comedian became one of the drug’s loudest honesty advocates, calling out stars who claim their results come from “pilates and a good diet.” In 2024 she revealed a Cushing syndrome diagnosis that explained facial swelling fans had noticed.
5. Tracy Morgan
Morgan told Hoda Kotb and Jenna Bush Hager on Today in February 2024 that he’s on Ozempic and it’s “got me on a leash.” His line: “I eat half a meal now.”
The 5 ft 10 in comic said he’d packed on about 40 lbs during the pandemic and that the drug essentially shut off his appetite. He’s paired it with regular workouts and stayed refreshingly casual about admitting it.
6. Whoopi Goldberg
Goldberg confirmed on The View in 2023 that she’d been using “that Mounjaro shot,” telling co-hosts she’d lost the equivalent of “almost two people.”
The 5 ft 5 in EGOT winner had previously lost weight after knee replacement surgeries and a 2019 bout of pneumonia and sepsis that nearly killed her. She’s framed the medication as a health decision, not a vanity one.
7. Charles Barkley
The Hall of Famer went on Ernie Johnson’s The Steam Room podcast and confirmed he’d used Mounjaro, dropping 60 lbs from a peak in the 350s.
Listed at 6 ft 6 in during his NBA career, Barkley played around 250 lbs and ballooned well past that in retirement. He’s credited the drug plus walking and cutting back on late-night eating, and hasn’t been shy about recommending it to friends.
8. Chelsea Handler
Handler’s confession on Call Her Daddy in January 2023 is one of the most-quoted of the entire Ozempic era: her anti-aging doctor handed her the drug without telling her what it was.
The 5 ft 7 in comedian said she only figured it out at a lunch where a friend mentioned her own Ozempic dose. Handler stopped taking it and gave her remaining supply away, saying she didn’t need it.
9. Kelly Clarkson
Clarkson told Whoopi Goldberg on The Kelly Clarkson Show in January 2024 that she takes a prescription weight-loss medication — but not Ozempic. She described it as a drug that “helps break down the sugar” after blood work showed she was prediabetic.
The 5 ft 3 in singer said her doctor pushed the idea for two years before she agreed. She’s credited walking around New York City and a higher-protein diet for the rest.
10. Robbie Williams
The former Take That singer confirmed in 2024 that he’s been using Ozempic, and he’s been unusually open about the trade-offs — including his worry about muscle loss and the unknown long-term effects.
At 6 ft 1 in, Williams has spoken for years about body image, depression and addiction recovery. He’s said the drug works but questioned whether he’ll be able to stay on it forever.
The denials
Plenty of stars have pushed back hard. Kyle Richards has repeatedly denied Ozempic use, crediting weight training, cutting alcohol and giving up sugar. Lizzo has attributed her results to a calorie deficit and strength training. Mindy Kaling has consistently declined to discuss the subject. Without a confirmation, it stays speculation.
The bigger shift isn’t the weight — it’s the honesty. Five years ago nobody admitted to anything more than “clean eating.” Now Oprah, Barkley, Morgan and Schumer are naming doses on camera, and that transparency is doing more to kill the shame around obesity treatment than any campaign ever did.
Frequently Asked Questions
How tall is Oprah Winfrey?
Oprah Winfrey is 5 feet 6.5 inches tall (169 cm). She is often rounded up to 5 ft 7 in when wearing heels on stage.
How much does Oprah Winfrey weigh?
Oprah Winfrey weighs approximately 160 pounds (73 kg). Her weight has fluctuated publicly for decades, peaking around 237 lbs in the early 1990s.
How old is Oprah Winfrey?
Oprah Winfrey was born on January 29, 1954, in Kosciusko, Mississippi, making her 71 years old as of 2025 (she turns 72 in January 2026).
What is Oprah Winfrey’s net worth?
Oprah Winfrey’s net worth is estimated at around $3 billion, built from The Oprah Winfrey Show, Harpo Productions, OWN, WeightWatchers equity and real estate.
Is Oprah Winfrey married?
Oprah Winfrey has never married. She has been in a committed relationship with businessman and author Stedman Graham since 1986.
What is Oprah Winfrey best known for?
She is best known for hosting The Oprah Winfrey Show (1986–2011), the highest-rated daytime talk show in U.S. television history, and for founding the OWN network.
How did Oprah Winfrey lose weight?
Oprah credits a combination of daily hiking and strength training, portion-controlled eating, and a prescription GLP-1 weight-loss medication she revealed using in 2023. She stepped down from the WeightWatchers board in 2024.
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Last Updated: September 21, 2026 | Source: Healthy Celeb
