Celebrities on GLP-1 Weight Loss Drugs
Semaglutide and tirzepatide changed Hollywood faster than any diet trend in decades. Ozempic, Wegovy, Mounjaro, Zepbound — the brand names became red carpet gossip by 2023, and by 2026 the conversation has shifted entirely. Nobody’s asking whether stars are using these drugs anymore. They’re asking which ones said it out loud.
That second group is smaller than you’d think. Plenty of celebrities have been accused, and plenty have flatly denied it. But a growing number decided transparency was better than dodging the question. Some lost significant weight and stayed on. Some quit after a week of vomiting. A couple have warned fans off the stuff entirely.
Here are the stars who’ve confirmed GLP-1 use on the record — what they took, how much they lost, and what they actually said.
1. Oprah Winfrey
Oprah broke the dam. In December 2023 she told People she was using a GLP-1 medication, calling it “a maintenance tool” and saying she no longer shames herself about weight. For a woman who’d spent 40 years as the public face of dieting — the 1988 wagon of fat, the 237-lb peak in 1992, the WeightWatchers partnership — it was a genuine shock.
She followed up by donating her WW shares and leaving the board in February 2024, then hosting the ABC special Shame, Blame and the Weight Loss Revolution that March. Standing 5 ft 6.5 in, Oprah says she keeps the medication as part of a routine with hiking and daily weight training, and wishes it had existed 30 years earlier.
2. Serena Williams
Serena went public in August 2025, revealing she’d been using a GLP-1 through telehealth company Ro — which her husband Alexis Ohanian has backed as an investor. The 23-time Grand Slam champion said she dropped 31 pounds and finally shifted weight that wouldn’t budge after the birth of her second daughter, Adira, in 2023.
At 5 ft 9 in and arguably the fittest athlete of her generation, Serena’s admission hit differently. Her point: she was still training, still eating well, and the scale wouldn’t move. She’s also reported better joint comfort and fewer knee issues since.
3. Elon Musk
Musk was early and casual about it. In October 2022, asked on X how he looked “fit, ripped & healthy,” he answered: “Fasting,” then added “Wegovy” in a follow-up. He later described the combo as fasting plus Wegovy plus keeping tasty food out of the house.
The 6 ft 2 in Tesla CEO has said he dropped around 30 pounds from a photographed high of 220 lbs, and has repeatedly praised the drug class as a net good for public health.
4. Whoopi Goldberg
Whoopi confirmed on The View that she’s been using Mounjaro, telling co-hosts she once weighed well over 300 pounds and has since lost what she described as “almost two people.” The 5 ft 5 in EGOT winner has been open that her weight was tied to a long struggle with food and mobility problems.
She addressed it again in her 2024 memoir Bits and Pieces and pushes back hard on the idea that medication is cheating. Her line: she tried everything else first, for decades.
5. Charles Barkley
Chuck told reporters in 2024 he’d lost about 60 pounds on Mounjaro and was thrilled about it. The 6 ft 6 in Hall of Famer played at 252 lbs in his prime but had crept well past 350 in retirement, something he joked about constantly on Inside the NBA.
Barkley credited the drug with cutting his appetite and said he paired it with walking and golf. He has no interest in pretending otherwise.
6. Tracy Morgan
Morgan told Hoda Kotb and Jenna Bush Hager on Today in January 2024 that he’s on Ozempic, joking that it only half works because he can still eat “half a cheesecake.” The comedian said he’d packed on 40 pounds during the pandemic.
Morgan, who’s about 5 ft 9 in, has type 2 diabetes in his family history and has talked openly about managing his health since the 2014 highway crash that nearly killed him.
7. Amy Schumer
Schumer tried Ozempic in 2022 and quit almost immediately. On Watch What Happens Live she said she was bedridden and throwing up, unable to play with her son. Her verdict: “That’s not livable for me.”
The 5 ft 7 in comic has since been one of the loudest voices calling out stars who deny using it while visibly shrinking. She’s also been candid about her Cushing syndrome diagnosis, which affected her weight and face.
8. Sharon Osbourne
Sharon’s is the cautionary tale. She lost 42 pounds on Ozempic and then couldn’t stop, dropping to around 95 pounds on her 5 ft 2 in frame. She came off the drug and told interviewers she still couldn’t put the weight back on, describing herself as too gaunt.
Her public warning — that people should be careful and that she went “too far” — has been quoted in basically every GLP-1 risk story since 2023.
9. Chelsea Handler
Handler’s story is the strangest here. On Call Her Daddy in January 2023 she revealed her anti-aging doctor had been giving her semaglutide without telling her what it was. She only figured it out when a friend mentioned Ozempic at lunch.
The 5 ft 4 in comedian said she didn’t need it, ditched the prescription, and gave the rest away. She’s since mocked the trend in her stand-up.
10. Kathy Bates
Bates lost 100 pounds over about seven years, and in a 2024 New York Times interview ahead of her Matlock reboot she credited Ozempic with about a third of it. The rest came from portion control and years of work after a type 2 diabetes diagnosis.
The 5 ft 3 in Oscar winner, who’s also managed lymphedema following a double mastectomy, says the weight loss gave her back energy she thought was gone for good.
11. Kelly Clarkson
Clarkson addressed the rumors in January 2024, telling Whoopi Goldberg on her own show that she is on a prescription weight-loss medication — just not Ozempic. She described it as something that helps her body break down sugar, prescribed after bloodwork, and said she’d resisted it for two years.
The 5 ft 3 in singer also credits walking everywhere in New York City and a protein-heavy diet. She’s been firm that the trigger was a pre-diabetic reading, not vanity.
The common thread across all 11? Almost every one tried everything else first. GLP-1s aren’t a shortcut story so much as a last-resort story that happened to work — and with cheaper compounded and oral options expanding in 2026, expect this list to keep growing.
Frequently Asked Questions
How tall is Oprah Winfrey?
Oprah Winfrey is 5 feet 6½ inches tall (169 cm). That places her slightly above the average height for an American woman.
How much does Oprah Winfrey weigh?
Oprah Winfrey weighs approximately 160 pounds (72.5 kg). Her weight has fluctuated publicly for decades, and she has spoken openly about it.
How old is Oprah Winfrey?
Oprah Winfrey was born on January 29, 1954, in Kosciusko, Mississippi, making her 71 years old. She is an Aquarius.
What is Oprah Winfrey’s net worth?
Oprah Winfrey’s net worth is estimated at around $3 billion, built from The Oprah Winfrey Show, Harpo Productions, OWN, WeightWatchers equity and real estate. She is one of the wealthiest self-made women in America.
Is Oprah Winfrey married?
Oprah Winfrey has never married, but she has been in a relationship with businessman and author Stedman Graham since 1986. They were engaged in 1992 but chose not to wed.
What is Oprah Winfrey known for?
Oprah Winfrey is best known for hosting The Oprah Winfrey Show (1986–2011), the highest-rated daytime talk show in U.S. television history. She is also an Oscar-nominated actress, producer and founder of the OWN network.
How did Oprah Winfrey lose weight?
Oprah has credited a combination of a GLP-1 weight-loss medication, daily hiking and strength training, and a lighter whole-food diet for her most recent transformation. She revealed in 2023 that she uses a prescription weight-loss drug as a maintenance tool, not a shortcut.
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Last Updated: October 1, 2026 | Source: Healthy Celeb
