Celebrities Who Stopped Taking GLP-1 Weight Loss Drugs
The Ozempic conversation has flipped. For a couple of years the gossip was about who was secretly on it. Now the more interesting question is who got off it — and what happened to their bodies afterward. Semaglutide and tirzepatide work brilliantly while you’re injecting them, but the research is blunt: stop, and most people regain a big chunk of the weight within a year.
A surprising number of famous people have gone on record about quitting. Some bailed after a single dose because the nausea was unbearable. Some stopped because they looked gaunt on camera. A few walked away worried about muscle loss. And at least one landed in a hospital.
Here are the celebrities who’ve publicly said they stopped taking GLP-1 drugs, and what they said about it.
1. Sharon Osbourne
Osbourne is the cautionary tale everyone cites. The TV host, who stands 5 ft 2 in, started Ozempic in late 2022 and dropped 42 lbs, bottoming out around 6 st 10 lb — about 95 lbs. She stopped after a few months and has repeatedly said she went too far, calling herself “too gaunt” and admitting she can’t put the weight back on.
Her line to the press in 2023 — that she’d warn anyone under 35 not to touch it — got quoted everywhere. Now 73, she’s said she’d tell her younger self to skip it entirely.
2. Amy Schumer
Schumer, 5 ft 7 in, quit after exactly one dose. She told Andy Cohen on Watch What Happens Live in 2023 that the shot left her “bedridden” and vomiting, unable to play with her son. Her verdict: “I couldn’t lift my head off the pillow.”
She’s since been vocal about celebrities lying about their use, and she’s tied her own body changes to a Cushing syndrome diagnosis rather than any injectable.
3. Chelsea Handler
Handler’s story is the funniest one on this list. On Call Her Daddy in January 2023, the 5 ft 5 in comedian revealed her “anti-aging doctor” had handed her semaglutide without telling her what it was. She only figured it out at a dinner party when everyone started comparing notes.
She stopped immediately. Her reasoning was simple — she didn’t need it, and she said she’d rather leave the supply to people with diabetes.
4. Charles Barkley
The 6 ft 6 in Hall of Famer went public with Mounjaro in 2023, saying it stripped 60 lbs off him. He was thrilled. Then he came off it — and admitted on air and on podcasts that a good portion of the weight came right back.
Barkley’s honesty about the regain made him one of the most-cited examples of what happens after you stop. He’s been transparent that the drug didn’t fix his eating habits; it just suppressed them temporarily.
5. Stephen Fry
The 6 ft 4 in British actor and broadcaster, born in 1957, tried a GLP-1 and abandoned it over relentless nausea. Fry described vomiting so severely that the trade-off stopped making sense, and he’s been open that he went back to conventional dieting afterward.
His account matters because gastrointestinal side effects are the single biggest reason people discontinue these drugs in real-world data — not cost, not plateaus.
6. Lottie Moss
The model, born January 1998, took Ozempic she got from a friend rather than a doctor — at a dose meant for someone far larger. She dropped to around 8 st (112 lbs), and in 2024 she described having a seizure and waking up in hospital.
Moss quit and has spent the time since warning young women off unprescribed injectables. She’s said the weight came back and that the whole thing wasn’t worth it.
7. Remi Bader
The content creator was prescribed Ozempic for prediabetes and said the aftermath was brutal. Speaking on the Not Skinny But Not Fat podcast, Bader explained that stopping triggered worse binge eating than before, and she gained back double what she’d lost.
She later underwent SADI-S bariatric surgery and has been candid about the 100-plus pounds she lost that way — plus the loose skin and the mental health work that came with it.
8. Robbie Williams
The Take That frontman, born February 1974, has talked openly about using weight-loss injections and about deciding to come off them. His stated concern was muscle mass — a legitimate one, since lean tissue can account for a significant share of GLP-1 weight loss without resistance training and high protein intake.
For a performer who does two-hour stadium shows, losing strength is a career problem, not a cosmetic one.
9. Dolores Catania
The Real Housewives of New Jersey star has been one of the most matter-of-fact celebrities about GLP-1s. Catania, born December 1970, has discussed using the medication, going off it, watching the weight return, and then going back on — the exact cycle clinicians now call maintenance dosing.
She’s also stressed the parts people skip: protein, weight training, and accepting it may be a long-term prescription rather than a short course.
The through-line here is simple. Almost everyone who stopped either couldn’t tolerate the side effects or didn’t have a plan for what came next. Compare that to Oprah Winfrey, who has framed her GLP-1 use as an ongoing maintenance tool rather than a temporary fix — and who stepped down from the WeightWatchers board in 2024 partly to speak freely about it. If you’re weighing these drugs, the exit strategy matters as much as the starting dose.
Frequently Asked Questions
How tall is Oprah Winfrey?
Oprah Winfrey is 5 feet 6½ inches tall (169 cm). She is often rounded up to 5 ft 7 in when wearing heels on stage.
How much does Oprah Winfrey weigh?
Oprah Winfrey weighs approximately 160 pounds (72.5 kg). Her weight has fluctuated publicly over four decades of well-documented dieting.
How old is Oprah Winfrey?
Oprah Winfrey was born on January 29, 1954, in Kosciusko, Mississippi, which makes her 71 years old as of 2025 and 72 in January 2026.
What is Oprah Winfrey’s net worth?
Oprah Winfrey’s net worth is estimated at around $3 billion, built from The Oprah Winfrey Show, Harpo Productions, OWN, real estate and her former WeightWatchers stake.
Is Oprah Winfrey married?
No. Oprah Winfrey has been in a committed relationship with businessman and author Stedman Graham since 1986, but the couple never married.
What is Oprah Winfrey best known for?
She is best known for hosting The Oprah Winfrey Show from 1986 to 2011, the highest-rated daytime talk show in U.S. television history, and for founding OWN and Oprah’s Book Club.
What diet and workout does Oprah Winfrey follow?
Oprah has long followed a portion-controlled, plant-forward eating plan popularized through her WeightWatchers partnership, and she stays active with daily hiking, walking, strength training and resistance work at her Montecito estate.
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Last Updated: September 18, 2026 | Source: Healthy Celeb
