Celebrity GLP-1 weight loss transformations 2026
Semaglutide and tirzepatide have rewritten how Hollywood talks about weight. Five years ago, stars credited “green juice and Pilates.” Now a growing list of them will tell you outright: they took the shot. And with compounded and lower-cost options flooding the market, plus Eli Lilly and Novo Nordisk slashing direct-to-consumer prices, the conversation has only gotten louder heading into 2026.
The problem is that speculation still outruns fact. Every dramatic red carpet slim-down triggers a wave of “did they use Ozempic?” posts, most of them guesswork. So here’s a sourced rundown of the celebrities who’ve actually said something on the record — the admissions, the numbers, the side effects that made some of them quit, and a couple of high-profile denials that keep getting misreported.
1. Oprah Winfrey
Oprah broke the celebrity silence first. In December 2023, she told People she was using a GLP-1 as a “maintenance tool,” calling it a relief after decades of public dieting. She stepped down from the WeightWatchers board in February 2024 and donated her shares, then hosted the ABC special Shame, Blame and the Weight Loss Revolution that March.
At 5 ft 6.5 in, Oprah has said her all-time high was 237 lbs in 1992 and that she’s hovered around 160 lbs recently. Knee surgery in 2021 restarted her hiking habit before the medication entered the picture; she still hikes three to five miles most days and lifts weights.
2. Serena Williams
The biggest name to go public in 2025. Serena revealed in August that she’d used a GLP-1 prescribed through telehealth company Ro — which her husband Alexis Ohanian had invested in — and dropped 31 lbs. She couldn’t shift the weight after her second pregnancy despite training like an athlete.
Serena stands 5 ft 9 in and competed at 155 lbs during her 23-Grand Slam career. She’s been blunt that the drug wasn’t a shortcut around exercise, and has since become a paid spokesperson for Ro’s weight-loss program, drawing both praise and criticism.
3. Kathy Bates
Bates promoted NBC’s Matlock in 2024 looking 100 lbs lighter, and explained exactly how. She told The New York Times the loss happened over about seven years, with Ozempic accounting for the final stretch — around 20 of those pounds.
The Oscar winner, 5 ft 3 in, was diagnosed as diabetic and said that health scare, plus losing her brother, pushed her to change. She eats far smaller portions and stops at 25 percent full, a habit she says stuck.
4. Charles Barkley
Barkley announced on Inside the NBA and in multiple 2024 interviews that Mounjaro helped him drop 62 lbs. The Hall of Famer had climbed to around 352 lbs, well above his 252-lb playing weight with the Suns and Rockets.
At 6 ft 6 in, Barkley says the biggest change was practical — walking 18 holes again without knee pain. He still works out and doesn’t consider the drug a free pass, calling the results “life-changing” while admitting he had to relearn how little food he needed.
5. Sharon Osbourne
Sharon’s is the cautionary tale. She started Ozempic in late 2022, lost 42 lbs, and said she went too far — dropping to around 95 to 100 lbs on a 5 ft 2 in frame. She says she can’t put the weight back on and regrets how thin she became.
She’s warned younger users that the drug isn’t meant for people who only want to lose 10 or 15 lbs, and has been candid about how gaunt the loss left her face.
6. Whoopi Goldberg
Whoopi confirmed on The View that she’d used Mounjaro, telling co-hosts she’d lost the equivalent of “almost two people.” She’s 5 ft 5 in and had been dealing with sciatica and mobility issues.
She framed it as a medical rather than cosmetic decision and pushed back on the shame attached to the drugs — a recurring theme among the older stars here who spent decades yo-yo dieting in public.
7. Tracy Morgan
Morgan told Jimmy Fallon in January 2024 that he was on Ozempic after packing on 40 lbs, joking that it “cut my appetite in half” — then adding that he still eats everything, just half of it.
The comedian, who is diabetic and had a kidney transplant in 2010, treats it as material. But the context is real: type 2 diabetes is what these drugs were approved for in the first place.
8. Meghan Trainor
Trainor confirmed in 2024 that she used a GLP-1 after her two pregnancies, saying she was tired of the speculation. She’s 5 ft 4 in and lost around 60 lbs.
She credits a combination — the medication plus a high-protein diet and regular personal training — and has noted the irony of the “All About That Bass” singer being scrutinized for shrinking.
9. Amy Schumer
Schumer tried Ozempic and quit fast. The dose left her “bedridden” and vomiting so badly she couldn’t play with her son, and she stopped within weeks. The 5 ft 7 in comedian has been one of the loudest voices calling out stars who deny using it.
In 2024 she also revealed a Cushing syndrome diagnosis after viewers commented on her puffier face — a reminder that not every visible change is drug-related, in either direction.
10. Kelly Clarkson
The most misreported case here. Clarkson told Whoopi Goldberg on her own talk show in January 2025 that she does take a prescription medication — but not Ozempic. She described a drug that helps her body break down sugar, prescribed after her doctor flagged her bloodwork.
The 5 ft 3 in singer credits walking everywhere in New York City and cutting processed food for most of the change, and says she resisted medication for two years before agreeing.
The pattern across all ten is consistent: the ones who talked openly got a news cycle, while the ones who dodged got months of speculation. With cheaper generics and a wider prescriber pool in 2026, expect more names to come forward — and expect the stats to keep shifting.
Frequently Asked Questions
How tall is Oprah Winfrey?
Oprah Winfrey is 5 feet 6½ inches tall (169 cm). That places her slightly above the average height for an American woman.
How much does Oprah Winfrey weigh?
Oprah Winfrey weighs approximately 175 pounds (79 kg). Her weight has fluctuated widely over four decades of publicly documented weight-loss journeys.
How old is Oprah Winfrey?
Oprah Winfrey was born on January 29, 1954, in Kosciusko, Mississippi. That makes her 71 years old, turning 72 on January 29, 2026.
What is Oprah Winfrey’s net worth?
Oprah Winfrey’s net worth is estimated at around $3 billion. Her fortune comes from The Oprah Winfrey Show, OWN network equity, Harpo Productions, real estate and investments including WW (Weight Watchers).
Is Oprah Winfrey married or dating anyone?
Oprah Winfrey has been in a relationship with businessman and author Stedman Graham since 1986. The couple got engaged in 1992 but chose never to marry.
What is Oprah Winfrey best known for?
Oprah Winfrey is best known for hosting The Oprah Winfrey Show from 1986 to 2011, the highest-rated daytime talk show in American television history. She is also an Oscar-nominated actress for The Color Purple and founder of the OWN network.
How did Oprah Winfrey lose weight?
Oprah credited her 2023–2024 weight loss to a combination of a GLP-1 weight-loss medication, daily hiking, strength training and portion-controlled eating. She publicly stepped down from the WW board in 2024 after revealing her use of the medication.
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Last Updated: September 28, 2026 | Source: Healthy Celeb
